Transfer of EPT-peptide gene into MDA-MB-231, SKOV. OVCAR and non-colony forming NIH 3T3 cells resulted in rapid death of MDA-MB-231, SKOV and OVCAR cells but not NIH 3T3 cells. These results support the conclusion that EPT-peptide can kill malignant cells but not the non-malignant cells.
Although EPT-peptide induces apoptosis of cancer cells, it does not induce apoptosis in the primary foreskin fibroblastic cells (CCD-1112SK).
EPT-peptide exerts its anti-cancer activity by binding to its specific cell membrane receptor molecules and triggering several signal transduction cascades.