Monthly Archives

April 2017

Osteoclast’s Impact in Causing Osteoporosis in Microgravity with and without Radiation Effect

By | Projects | No Comments

The causes of osteoporosis in microgravity may be manifold. Most of the research has been dedicated to studying bone weight loading, muscle atrophy, osteoblastic biocellular changes and paratharmone effects. These studies are focused on bone formation while little research has been performed on bone resorption. ISMC has focused on the the resorption mechanism of the osteoclast at 1-G, hyper-G during transport and in micro-gravity.

We have applied mathematical modeling to confirm our understanding of the effects of osteoblast/osteoclast changes on the balance of bone formation. Multivariable analysis helps understand how the molecular biological changes of the osteoclast in micro-gravity, with and without radiation, effects osteoporosis.

Space radiation ((gamma, proton, carbon and ion) increases the bone loss risks of microgravity exposure. This leads to premature onset of osteoporosis, fractures, arterial calcification, mineral leaching and decreased bone quality. Literature has shown that serum markers for bone formation and resorption from the ion radiation exposed rats have indicated that the bone loss is caused by increased osteoclastic bone resorption. During space flight, osteoclast activation through skeletal unloading has also been noted to cause bone loss. ISMC plans to add studies of the mechanisms associated with increased osteoclastogenesis under exposure to space radiation. We understand that osteoporosis after radiation therapy is also a problem.

This will enable not only the development of suitable anti-resorptive countermeasures requiring minimal intervention, but also in ascertaining optimal dosage for therapy. Our modeling with our University partners will help us predict the threshold RANKL concentration likely to induce increased osteoclast genesis in microgravity.

Our studies and research interest of the osteoclast can lead to new pharmaceuticals that can interfere with bone resorption in MicroG; however, the findings can also be used to prevent osteoporosis at 1G.

ISMC welcomes collaboration with experts, universities, government agencies and corporations

Osteoporosis after radiation therapy is a problem.

Interactive Behavioral Health Psychologist Persona

By | Projects | No Comments

International Space Medicine Consortium Inc with support from its affiliate company, Forever Identity (www.foreverIdentity.it) in Milan/Genoa Italy, have applied our patented (issued and Pending) Dialog stimuli recognition management, emotion/empathy platform and ethical/morality AI subset to space medicine applications.  This scientific/engineering research and application specific product development is further supported by our internal research and development AI, HCI /Voice Recognition, Expert Systems team, consultants and subcontractors. We seek and engage AI partners for NLG and machine learning.

ISMC has created a model for an Interactive Behavioral Health Psychologist for space mission long term group isolations. In association with leading psychologists who focus on emotional intelligence and analysis of facial expression, ISMC’s Senior Advisor on Human Persona Robotics HCI has created an emotional, empathetic Persona that can interact with a person through biosensors and expert psychological behavioral health knowledge. The interaction is compared to an individual baseline emotional pattern to changes measured during the present interaction. Facial expression, biosensors, body movements and voice modulations will be integrated into the Persona through its Hierarchy Matrix that prioritizes input importance. The Persona has the ability to learn and interact with evolving emotional and behavior health changes.

The evolution of this Behavioral Health Psychologist Persona can be used on an everyday basis on earth. Initially it can be used for people or groups in isolated positions. Eventually the Persona through AI will fill the void occurring due to the decreasing number of psychiatrists and behavioral health workers. Once an early detection of a behavioral health problem is identified, modalities of treatment, such as cognitive therapy, can be suggested.

ISMC welcomes experts, universities, government and corporate partners who can help the evolution of the Behavioral Health Psychologist Persona and who can assist our team to create Cognitive Treatment Intelligence for the Persona to suggest treatments to counter the emotional changes realized.

The effects of e‐peptide on breast cancer Tumor cells and mesenchymal stem cells in microgravity

By | Projects | No Comments

ISMC, and its affiliate company, E-P Therapeutics Inc, have been studying the application of our discovery and patent protected Human E-Peptide (designated as hEb) in microgravity as a part of our interest in the Humans in Space and Microbes in Space programs.  The hEb has been shown to down-regulate malignant cellular growth and kill many different malignant cell lines by apoptosis.  Cancer cells that have been studied are:

  • Breast cancer cells (MDA-MB-231 and ZR-75-1)
  • Colon cancer cells (HT29)
  • Hepatoma cells (HepG2)
  • Leukemia cells
  • Neuroblastoma cells (SK-N-F1)
  • Ovarian cancer cells (SKOV and OVCAR)
  • Protease cancer cells (PC3)
  • Small lung cancer cells (NCI-H526F)

Our hEb represents the cleavage of the terminal carboxy end of a pro-IGF-1 molecule. When cleavage occurs, IGF-1 is released and hEb is found as independent molecules. It is water soluble and heat-resistant, and it also has an anti-angiogenesis effect by inhibiting endothelial cell growth. There is evidence that hEb has an inhibitory effect on malignant stem cells.

Studies demonstrate that mesenchymal stem cells (MSC) enhance neoplastic growth while others demonstrate an anti-tumorigenic quality. It is known that MSC have the ability to migrate to tumor sites and react with tumors. MSC can also respond to inflammation around the tumor and deliver cytokines, necrosis factor and interleukin-6, around the tumor environment. The interaction of hEb and mesenchymal stem cells should potentiate tumor necrosis.

 

Our ISMC research has considered the hyper-G and micro-G challenges associated with transport to the ISS. We understand that the proliferation of malignant MDA-MB231 breast cancer cells in microgravity to be greater than the same tumor cells grown at 1G.  Our aim is to test the ability of hEb to respond to faster growing tumor cells and demonstrate its ability to function in a very aggressive environment. MDA-MB231 breast cancer cells in micro-gravity have cell survival up-regulated. This will challenge hEb’s ability to kill cancer cells by apoptosis. Mesenchymal Stem Cells will also be tested against the breast cancer cells to evaluate its effect on tumor growth. The effect of E-Peptide on MSC will also be observed. If successful, this study would demonstrate the potential for hEb to be developed as a novel chemotherapeutic agent. It will also show the effects of Mesenchymal Stem Cells on tumor growth and its use in cancer treatment.

 

ISMC welcomes inquiries from research organizations, universities, government and corporate partners to accelerate our project and to participate in the health and well-being of humanity in the exploration of space and interplanetary colonization.

Life Support Systems for Manned Mars Missions, Overview

By | News | No Comments

Congratulations to ISMC Board member & Chief Medical Officer Dr. Thais Russomano on the publication of her book chapter – Life Support Systems for Manned Mars Missions, Overview –  a part of the Handbook of Life Support Systems for Spacecraft and Extraterrestrial Habitats, Published by Springer International Publishing. This Living Reference Work will develop and grow over the coming months to focus on all aspects of a manned trip to Mars, for example, the climate that will await space travelers, the life support systems necessary to keep them alive on the journey and on the planet, the dangers posed by space radiation, and the physical and psychological effects of living in an extreme environment 54.6 million kilometers away from friends and family on Earth.

Dr. Russomano is a leading international authority in Space Life Sciences, specializing in the effects of low-gravity and microgravity environments on the human body. She is a published author of numerous scientific articles in peer-reviewed journals and Chapters in books, as well as having published 6 books in the areas of Astronomy, the Space Life Sciences, and Aerospace Biomedical Engineering.

The Chapter abstract (doi: 10.1007/978-3-319-09575-2_188-2) can be accessed at the Springer Link website.

#Mars #SpaceTravel

ISMC STEM/STEAM SUPPORT OF SCIENCE DAYS 2017 IN Brazil

By | News, Projects | No Comments

The Science Days 2017 was held from March 12th – March 18th in Brazil to raise awareness of the benefits of STEM worldwide.

Science Days was created based on Florida’s Space Day which is a milestone event that presents an opportunity to educate and bring awareness to legislators and general public on the significance of the aerospace industry and its impact on Florida’s economy.

​In Brazil, Science Days are held on school and university campuses and are administered by the BFCC Board Council, School Councilperson, and the University Council. Currently two very reputable schools and universities will host Science Days Brazil.

#Edutainment #AE

For more information visit http://www.brazilflorida.org/